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Correlation of serum cholestryl ester transfer protein (CETP) level with lipid profile in young myocardial infarction patients

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Original Article

Author Details : Rashmi Gulia*, Bharti Uppal, Rajender Chawla, Rajneesh Calton

Volume : 6, Issue : 3, Year : 2019

Article Page : 363-368

https://doi.org/10.18231/j.ijcbr.2019.079

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Abstract

Introduction: Heart Disease is number one cause of mortality and a silent epidemic among Indians. The
risk of coronary artery disease is found to increase with increase in serum Cholesteryl ester transfer protein
(CETP) levels. CETP mediates the exchange of lipids between the lipoproteins. Serum CETP levels of
young myocardial infarction (MI) patients are measured to see its correlation with lipid profile.
Materials and Methods: This prospective observational case-control study was done on 50 young MI
patients and 30 age-matched controls for measuring serum CETP and lipid profile in the biochemistry
laboratory of Christian medical college, Ludhiana. The study started from 1st November 2014 till full
enrolment. Serum CETP were quantified by Enzyme Linked Immunosorbent Assay (ELISA) method.
Results: The mean serum CETP value observed among cases was 1168.7738.3 mg/L and that among
cases was 978.4337.2 mg/L with a p-value was 0.18. The correlation coefficients of serum CETP with
total cholesterol, triglyceride, Low density lipoprotein and high density lipoprotein are -0.083, -0.037,
-0.020 and 0.050 and similarly among controls were -0.292, 0.086, 0.282, 0.337 respectively.
Conclusion: The serum CETP concentrations were found to be higher in cases as compared to the controls
but were not found to be statistically significant, while no correlation was found between serum CETP.

Keywords: Myocardial infarction, Serum CETP levels, Lipid profile, Lipoproteins, ELISA assay concentration and lipid profile in young MI cases.

 

How to cite : Gulia R, Uppal B, Chawla R, Calton R, Correlation of serum cholestryl ester transfer protein (CETP) level with lipid profile in young myocardial infarction patients. Int J Clin Biochem Res 2019;6(3):363-368

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