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An association of anti-thyroid peroxidase antibodies in clinical and subclinical hypothyroidism

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Original Article

Author Details : Jusmita Dutta, Shweta Jain*, Ashish Jain, Swapnil Jain, Swati Jain

Volume : 6, Issue : 3, Year : 2019

Article Page : 415-420

https://doi.org/10.18231/j.ijcbr.2019.089

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Abstract

Introduction: Among general people anti-thyroid antibodies and thyroid profile (TSH, T4, and T3) relation
is not established. In several years presence of Anti-TPO antibodies may lead to progress of clinical
thyroid disease. Therefore, to rule out underlying autoimmune method screening for Anti-TPO antibodies
is required. Aim of the present study was to find an association of Anti-TPO antibodies in clinical and
subclinical hypothyroidism.
Materials and Methods: A cross sectional study was conducted in department of medicine and
biochemistry involving 74 cases and 74 controls during the period of December 2017 to December 2018.
Patien ts history, clinical examination and various investigations including FT3, FT4, TSH, Anti-TPO, FBG
and lipid profile were done.
Results: Out of 74 cases 30 cases had clinical hypothyroidism and 44 cases have subclinical
hypothyroidism. 63.5% cases of hypothyroidism were Anti-TPO positive. 70.3% cases of Clinical
hypothyroidism were Anti -TPO positive and subclinical hypothyroidism had 51.5% Anti-TPO positive.
TSH had a significant positive correlation with Anti-TPO antibodies.

Keywords: AntiTPO, Clinical hypothyroidism, Subclinical hypothyroidism, TSH, AntiTPO, Clinical hypothyroidism, Subclinical hypothyroidism, TSH.

How to cite : Dutta J, Jain S, Jain A , Jain S , Jain S, An association of anti-thyroid peroxidase antibodies in clinical and subclinical hypothyroidism. Int J Clin Biochem Res 2019;6(3):415-420

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