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- DOI 10.18231/j.ijcbr.11445.1760587515
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CrossMark
Anti-inflammatory role of scent leaf (Ocimum Gratissimum L.) and bitter leaf (Vernonia Amygdalina D.) on simulated gastrointestinal digestion
- Author Details:
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Umoh Esther Udoa
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Oyubu Godspower
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Kpomah Bridget
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Daramola Festus Olayinkad
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Asimi Tawakalitu Temitope
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Julius John Dimasf
Umoh Esther Udoa
Oyubu Godspower
Background: Inflammation can be described as a part of the body’s immune response to any kind of injury or infection. Some of its symptoms include pain, redness, heat and swellings. Inflammation could be acute or chronic depending on the type. Many drugs have been developed to tackle different form and kinds of inflammations. Most of these drugs are called non-steroidal anti-inflammatory drugs [NSAID]. Many of these drugs have side effects. Therefore, most researchers focus their research activities and objectives in exploring less toxic and yet effective drugs that can serve as an effective anti-inflammatory drugs with little or no side effects. Numerous research have shown that plants have vast medicinal properties which are well documented in several publications. The anti-inflammatory potential of medicinal plants stands out amongst its numeorus medicinal values and have been employed in ethno- medicine and modern medicines.
Aim and Objectives: This research is aimed at investigating Anti-inflammatory role of scent leaf (Ocimum Gratissimum L.) and bitter leaf (Vernonia Amygdalina D.) on simulated gastrointestinal digestion.
Materials and Methods: Methodologies employed here are well elucidated in this article.
Results: The results obtained showed a remarkable decrease in all inflammatory parameters
Conclusion: The research justifies and makes these plants (Ocimum Gratissimum L.) and bitter leaf (Vernonia Amygdalina D.) a potential anti-inflammatory drugs
References
- Akpaso MI, Atangwho IJ, Akpantah A, Fischer VA, Igiri A, Ebong E. Effect of Combined Leaf Extracts of Vernonia amygdalina (Bitter Leaf) and Gongronema latifolium (Utazi) on the Pancreatic β-Cells of Streptozotocin. Brit J Med & Medical Rese. 2011;1(1):24-34. https://doi:10.9734/BJMMR/2011/215
[Google Scholar] - Ho WY, Liang WS, Yeap SK, Beh BK, Yousr AHN. In vitro and in vivo antioxidant activity of Vernonia amygdalina water extracts, Afric J Biotech., 2012;11(17):4090–4. https://doi:10.5897/AJB10.1639
[Google Scholar] - Farombi EO, Owoeye O. Antioxidant and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid. Int J of Environ Res Pub Health. 2011;8:2533–55. https://doi:10.3390/ijerph8062533
[Google Scholar] - Hamzah RU, Jigam AA, Makun HA, Egwin EC. Antioxidant Properties of Selected African Vegetables, Fruits and Mushrooms: A Review. Intech 2013;9:203-50.
- Ilori, M.,Sheteolu, A.O., Omonibgelin, E.A. and Adeneye, A.A. (1996). Antibacterial activity of Ocimum gratissimum (Laminaceae). s. 14: 283-5. https://doi:10.1590/S0074-
[Google Scholar] 02761999000500022 - Iwu MM. Handbook of African Medicinal plants. CRC Press, New York. 1993;Pp: 214-215.
- Onajobi FD. Smooth Muscle Contracting Lipid Soluble Principles in Chromatographic Fractions of Ocimum gratissimum. J Ethanopharm. 1986;18(1):3-11. doi:10.1016/0378-8741(86)90038-3
[Google Scholar] - Orwa, C., Mutua, A., Kindt, R., Jamnadass, R. and Anthony, S. (2009). Agroforestree Database: A Tree Reference and Selection Guide Version 4.0. http://www.worldagroforestory.org/site/treedatabases.asp
- Ahmed A.U. An overview of inflammation: mechanism and consequences. Front Biol. 2011l;6(4):274–81. https://doi:10.1007/s11515-011-1123-9
[Google Scholar] - Hotamisligil G.S. Inflammation and metabolic disorders. Nature. 2005;;444(7121):860–7. https://doi:10.1038/nature05485
[Google Scholar] - Virshette SJ, Patil MK, Somkuwar AP. A review on medicinal plants used as anti inflammatory agents. J Pharmacogn Phytochem. 2019;8(4):1641–6.
- Liu CH, Abrams N, Carrick DM, Chander P, Dwyer J, Hamlet MRJ. Biomarkers of chronic inflammation in disease development and prevention: Challenges and opportunities. Nat Immunol. 2017;18(11):1175–80. https://doi: 10.1038/ni.3828
[Google Scholar] - Fialho L, Cunha-E-Silva JA, Santa-Maria AF, Madureira FA, Iglesias AC. Comparative study of systemic early postoperative inflammatory response among elderly and non-elderly patients undergoing laparoscopic cholecystectomy. Rev Col Bras Cir. 2018;45:e1586. https://doi:10.1590/0100-6991e-20181586
[Google Scholar] - Jang CH, Kim YY, Seong JY, Kang SH, Jung EK, Sung CM, Kim SB, Cho YB, Sung JY. Clinical characteristics of pediatric external auditory canal cholesteatoma. Int J Pediatr Otorhinolaryngol. 2016;87:5–10. doi:
- 1016/j.ijporl.2016.05.029.
- Esther U. U., Emmanuel O. I., Olaide B. B., Adewale A. O., Godspower O. (2025). “Therapeutic roles of Aframomum Melegueta on Testosterone Propionate Induced Benign Prostrate Hyperplasia in Wistar Rats. IJCBR 12(1):24-30. https://doi:10.18231/j.ijcbr.2025.004
[Google Scholar] - Gil-Izquierdo A., Gil MI, Ferreres F. Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds. J Agricultural Food Chem. 2002;50(18):5107-14.
- Truscheit E, Frommer W, Junge B, Müller L, Schmidt DD, Wingender W. Chemistry and biochemistry of microbial α‐ glucosidase inhibitors. Angewandte Chemie International Edition in English, 1981;20(9):744-61. https://doi.org/10.1002/anie.198107441
[Google Scholar] - Di Bella G, Mascia F, Gualano L, Di Bella L. Melatonin anticancer effects. Int J Mol Sci.2013;14(2):2410-30. https://doi:10.3390/ijms14022410
[Google Scholar] - Kulkarni A, Govindappa M, Chandrappa CP, Ramachandra YL, Koka PS. Phytochemical analysis of Cassia fistula and its in vitro antimicrobial, antioxidant and anti-inflammatory activities. Adv Med Plant Res. 2015;3(1):8-17.