Evaluation of Serum Adenosine Deaminase (ADA) Values for Detection of Pulmonary and Extra-pulmonary Tuberculosis

• Author Details:   
• Abhijit Ninghot
• Kanchan Mohod
• Satish Kumar

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Introduction: There is need of precise and faster diagnosis for pulmonary (PTB) and extra-pulmonary tuberculosis (EPTB). Accordingly, there develops a considerable interest in the development of tests based on biochemical response of body towards tuberculosis infection (i.e. estimation of serum adenosine deaminase). These tests appear to be a promising approach for the diagnosis of pulmonary as well as extra pulmonary TB.
Materials & Method: Total 150 individuals recruited for this study, out of which 50 cases each of PTB and EPTB. 50 age and sex matched controls were included, out of which 15 were healthy controls and 35 were diseased controls. Serum adenosine deaminase (ADA) was estimated by using commercial ADA-MTB kit.
Results: Serum ADA concentration in patients with PTB & EPTB was found to be significantly higher (p < 0.05) as compared to diseased and healthy controls.
Conclusion: Our observations suggest that serum Adenosine deaminase (ADA) measurement has a good detection potential for PTB & EPTB.

Keywords: Adenosine Deaminase, Pulmonary and Extra-Pulmonary Tuberculosis