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Evaluation of serum beta HCG levels in pregnant females as a predictor of gestational hypertension

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Original Article

Author Details : Nancy Goyal, Divmehar Kaur, Maninder Kaur, Jasvir Singh*, Parneet Kaur

Volume : 7, Issue : 3, Year : 2020

Article Page : 361-366

https://doi.org/10.18231/j.ijcbr.2020.078

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Abstract

Background: Human b -HCG is a glycoprotein that is expressed in trophoblastic cells and various
malignant tumors. Placenta is the known primary trigger of gestational hypertension. Beta HCG is secreted
in abundance from placenta.
Aims and Objectives: The aim of the present study is to estimate the serum Beta HCG levels in study
group consisting of 50 patients (Pregnant Females) of gestational hypertension and in control consisting of
same age matched pregnant females.
Materials and Methods: The present hospital based observational and analytical study was conducted on
80 patients out of which 50 were diagnosed with gestational hypertension and 30 constituted the control
group. The Beta HCG levels were analyzed by Sandwich ELISA Method.
Results: The results of the present study showed that there was increase in Beta HCG levels in the
gestational hypertensive patients with a mean value of Beta HCG was 117.79 ± 57.7mIU/ml, mean value
of Systolic blood pressure was 127.3 +13.9 mm of Hg and mean value of Diastolic blood pressure was 78.6
+16.1 mm of Hg which were statistically significant (p=<0> Conclusion: Serum Beta HCG levels were elevated in gestational hypertension, when compared with
controls. Due to trophoblast response to hypoxia there exists an abnormal secretory function of the placenta
in cases of gestational hypertension which leads to development of a hypersecretory state which is seen as
a rise in Beta HCG levels. This study showed that estimating serum Beta HCG levels is a useful indicator
to identify women who are likely to develop gestational hypertension in the same pregnancy.

Keywords: SBP(Systolic Blood Pressure), DBP(Diastolic Blood Pressure), b -HCG (Beta Human Chorionic
Gonadotrophin), GHT(Gestational Hypertension), IUGR(Intra Uterine Growth Restriction), LBW (Low Body Weight)
ELISA (Enzyme Linked Immuno Sorbent Assay).

How to cite : Goyal N , Kaur D , Kaur M , Singh J , Kaur P , Evaluation of serum beta HCG levels in pregnant females as a predictor of gestational hypertension. Int J Clin Biochem Res 2020;7(3):361-366

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